Selected Publications
[Google Scholar] Exploring the role of exome sequencing in newborn screening.
A.N. Adhikari, et. al.
Nat. Med. In Press (2020)
Genomic Analysis of Historical Cases with Positive Newborn Screens for Short-Chain Acyl-CoA Dehydrogenase Deficiency Shows That a Validated Second-Tier Biochemical Test Can Replace Future Sequencing
A.N. Adhikari, R.J. Currier, H. Tang, C.T. Turgeon, R.L. Nussbaum, et. al.
Int. J. Neonatal Screen. 2020, 6(2), 41 (2020)
Perturbation robustness analyses reveal important parameters in variant interpretation pipelines
Y. Wang*, A.N. Adhikari*, U. Sunderam, M.N. Kvale, et. al.
Preprint biorxiv (2020)
*Co-first authors
Gene‐specific features enhance interpretation of mutational impact on acid alpha‐glucosidase enzyme activity
A.N. Adhikari.
Hum. Mut. 2019; 40: 1507– 1518.(2019)
Lessons from the CAGI-4 Hopkins clinical panel challenge.
J-M. Chandonia, A.N. Adhikari, M. Carraro, A. Chhibber, G.R. Cutting, Y. Fu, A. Gasparini,
D.T. Jones, A. Kramer, K. Kundu, H.Y.K. Lam, E. Leonardi, J. Moult, L.R. Pal, D.B. Searls,
S. Shah, S. Sunyaev, S.C. E. Tosatto, Y. Yin, B.A. Buckley
Hum. Mut. Accepted (2017)
Aromatic claw: A new fold with high aromatic content that evades structural prediction.
J.R. Sachleben, A.N. Adhikari, G. Gawlak, J. Hinshaw, R. J. Hoey, G. Liu, K. F. Freed, A.
Joachimiak, G. Montelione, T. R. Sosnick, S. Koide.
Prot. Sci. 26.2: 208-217. (2017)
Bcl11b defect in a human severe combined immunodeficiency with multisystem anomalies.
D. Punwani, Y. Zhang, J. Yu, M. Cowan, S. Brenner, A.N. Adhikari, A. Chellappan, A. Kwan,
B. Mendelsohn, S. Rana, R. Srinivasan, D. Weist, J. Puck
New. Engl. J. Med. 375:2165-2176 (2016)
Even with nonnative interactions, the updated folding transition states of the homologs Proteins G and L
are extensive and similar.
M. Baxa, W. Yu, A.N. Adhikari, D. Ge, Z. Xia, R. Zhou, K.F. Freed, T.R. Sosnick
Proc. Natl. Acad. Sci 112, 27 (2015)
Simplified protein models: Predicting folding pathways and structure using amino acid sequences.
A.N. Adhikari, K.F. Freed, T.R. Sosnick.
Phys. Rev. Lett. 111, 028103 (2013)
De novo prediction of protein folding pathways and structure using the principle of sequential stabilization.
A.N. Adhikari, K.F. Freed, T.R. Sosnick.
Proc. Natl. Acad. Sci. USA 109,17442 (2012)
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The folding transition state of Protein L Is extensive with nonnative interactions (and Not Small and Polarized).
T.Y. Yoo, A.N. Adhikari, Z. Xia, H. Tien, K.F. Freed, R. Zhou, T.R. Sosnick.
J Mol. Biol. 420(3):220-234. (2012)
Modeling large regions in proteins: Applications to loops, termini and folding.
A.N. Adhikari, J. Peng, M. Wilde, J. Xu, K.F. Freed and T.R. Sosnick.
Prot. Sci. 21(1):107-121(2012)
Heterogeneous dynamics and dynamic heterogeneities at the glass transition probed with single molecule spectroscopy.
A.N. Adhikari, N.A. Capurso, D. Bingemann.
J. Chem. Phys., 127 (8), 114508 (2007)
Exploring pathway diversity in protein folding using sequential stabilization.
A.N. Adhikari, K.F. Freed, T.R. Sosnick
Preprint (2017)
A computational framework for insertion of lanthanide-binding tags (LBT) in membrane proteins
A.N. Adhikari, et. al.
Preprint (2017)
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