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The G. Ames Lab
P.I. : Giovanna Ferro-Luzzi Ames Staff : Calvin Hu, David Kreimer, Kishiko Nikaido, Iris Wang, Sue Zhang Undergrad : Erick Lin (recent graduate, soon to be hired!)
Goals The research conducted in our lab focuses on the histidine permease transport system of the Salmonella typhimurium. We are interested in elucidating the mechanism of signal transduction across the membrane-bound complex HisQMP2 through an interaction with the periplasmic receptor HisJ. The interaction of HisJ with the HisQMP2 complex induces ATP hydrolysis in the HisP subunits of the complex and allows for substrate translocation across the inner membrane of the bacteria. Current work includes studies of HisP mutants, developing HisM antibodies, and chemical cross-linking analysis. |
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