PWComp

a graph comparative metabolic pathway tool
 



  Introduction

  Team Profiles

  Software Architecture

  Documentation

  Download

  Future Development

 


Team Members


Joshua L. Adelman ( / homepage)

Joshua is a first year Ph.D. student in the Biophysics Graduate Group at U.C Berkeley. He is currently completing the rotation phase of the program in several computational laboratories. He received a B.S. in Biology with a concentration in Biophysics from Haverford College in 2001. During the intervening years, Joshua conducted fluorescence microscopy research at the German Cancer Research Center (DKFZ) in Heidelberg, Germany and was in residence at Harvard University doing single molecule spectroscopy.

Project Contributions:

Computational Engine:
- Implementation of the Heymans algorithm and Hungarian Algorithm
- Supporting classes to convert Pathway Graph into an Enzyme Graph, and to calculate similarity scores between reactions.
Container Classes:
- Simple modifications to some container classes as well as design suggestions
GUI:
- Implementation of JUNG graph renderer and GUI layout


Josh England ( )

Josh is a researcher in the field of high performance computing and networking, currently working at Sandia National Laboratory. He received a B.S. in computer science from the New Mexico Institute of Mining and Technology, and has done research while employed at the Energetic Materials Research and Testing Center in Socorro, NM, and Integrated Genomics, Inc. in Chicago, IL.

Project Contributions:

Data Input and Container Classes:
- Parsers for BioCyc data
- Design and implementation of container classes
Pathway Graph:
- Construction of Pathway Graphs
GUI: Implementation of JUNG graph renderer and GUI layout


Alex Chen ( )

Alex is fourth year undergraduate in the department of Electrical Engineering and Computer Science at UC-Berkeley.

Project Contributions:

Perl Scripts to find E.C numbers: - Implement various methods to get EC number for each enzyme(protein), either by looking through local dat files, or access swissprot database remotely, or BLAST the sequence to find and use the EC number of its similar enzyme(protein).

- This code does not directly link into PWComp. It's interaction is a goal for future releases, however at this time we do not guarantee its functionality. (Download)