Computational Biology

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  • What is a sequence alignment? (Pachter)
    • What is the Needleman-Wunsch algorithm? (Pachter)
    • What is the running time of this algorithm? (Pachter)
    • How can this algorithm be used to find the maximal increasing subsequence of a permuation? (Pachter)
    • Can you think of another way to find this maximal subsequence using the RSK algorithm? (Pachter)
    • What is the running time of this algorithm? (Pachter)
  • What is the Hammersley Clifford theorem from undirected graphical models? (Song)
    • about the Conditional Independence statements, what is the smallest subset of statements needed to describe the graph? (Song)
    • How do you find the marginalization of one of the variables? Ans: junction-tree algorithm, sum-product algorithm. (Song)
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