Baja California, 2003
|
|
Research Interests: Computational studies of biological systems
- Immunological synapse
- Polymer dynamics in disordered media
- Transport in the nuclear pore complex
¡¡
My
Stanford webpage |
|
Information transfer between immune cells
- understanding immunological
synapse formation
- S.J.E. Lee, Y. Hori, J.T. Groves, M.L. Dustin and A.K.
Chakraborty,
"Correlation of a dynamic model for immunological synapse
formation with effector functions: two pathways to synapse formation",
Trends in
Immunology, 2002, 23, 492¡¡
- S.J.E. Lee, Y. Hori, J.T. Groves, M.L. Dustin and A.K.
Chakraborty,
"The synapse assembly model",
Trends in
Immunology, 2002, 23, 500
-
S.J.E. Lee, Y. Hori and A.K. Chakraborty,
¡°Lower TCR
Expression and Thermal Fluctuations Contribute to Formation of Dynamic
Multifocal Synapses in Thymocytes¡±,
PNAS, 2003
Weak attraction facilitates transport - dynamics of random heteropolymers
in disordered media
Dynamics of an A-type homopolymer in quenched disordered
media is shown as
a movie(r=0.40, T/Tref=5.0,
N=30). For clarity, the disordered particles are not shown.
The colored balls represent each segments of the polymer chain. For
visualization
purposes, the segments are color coded from red to yellow. Each snapshot
displays the
time averaged position of each polymer segment in 5000 Monte Carlo step
intervals.
Majority of the time, the polymer is trapped in a void space undergoing
conformational
rearrangements. Occasionally one end of the chain enters a narrow channel.
This does not
guarantee escape from the void space. In the middle of the movie(18 sec in
movie time),
the polymer inserts its red end into a narrow channel, and is successful in
translocating itself through the narrow channel to a neighboring void space.
Similar
observations of translocation a confined polymer through a hole is described
by M.
Muthukumar(M. Muthukumar, Phys. Rev. Lett. 86, 3188 (2001)).
|
