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The Natural Band-Aid®

Using engineered collagen for wound treatment

Melody Pongmanopap

Fall 2005

collagen wound treatment tendon peptide bandage band aid    Collagen, present in ligaments, tendons, bones, cartilage, and blood vessel walls, is a vital component of the body’s connective tissue. Its elasticity keeps our skin flexible, and its degradation over time manifests itself through wrinkles. With the recent trend in medical science towards using natural substances to reduce the occurrence of undesirable side effects, it is unsurprising that collagen, which constitutes 60 percent of the body’s total protein content, is the target of many new approaches to medical treatment.

    If collagen is modified with various peptides, it can lead to the development of a more effective bandage, one which not only fights infection, but also prevents the formation of scar tissue. Michael Yu, PhD, at Johns Hopkins University has discovered a way to transform collagen’s triple helix structure by simply mixing it with smaller biological molecules.

    In the Journal of the American Chemical Society, Yu reported that instead of using the customary technique of applying extreme heat to modify collagen, mixing it with small molecules called collagen mimetic peptides proved to be much more compatible with the human body. Scientists believe that since the peptides possess triple helix structures, they can easily interact with collagen molecules, giving it numerous additional properties.

    Even by itself, collagen benefits the body by attracting cells to seal a wound and form scar tissue. However, this can be dangerous if the scar tissue interferes with peripheral nerve regeneration, such as in blood vessels. Moreover, collagen can be altered with a substance known as polyethylene glycol to make it actually repel cells. Yu’s research team found that in a lab dish, cells migrated towards the untreated collagen but shied away from the modified kind. He believes that this modification can be used to prevent scarring after certain injuries.

    Research concerning the medical uses of collagen is not entirely new. Scientists at Texas A&M University have also found that collagen is an excellent treatment for wounds. Douglas Miller, PhD, found that when poured or injected into open wounds, collagen can decrease the time it takes for the wounds to heal by 50 percent. However, while it is easy to mold collagen to fit a given wound, it does not bind directly to the site of injury in vivo.

    Miller and other researchers solved this problem by using a polymerization process to create a mixture of collagen and other molecules that facilitates the direct binding of collagen to wounds. The texture of the synthetic material is gelatinous and flexible, but unlike gelatin itself, this newly-engineered collagen can rise and fall according to a body’s movements without tearing.

    Miller and other scientists believe that collagen may have many other medical applications, including drug delivery. Although research on collagen’s medical applications is still in its nascent phase, this versatile protein provides the potential for a plethora of medical advances.

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